So, Heavy Rain. Pretty awesome PS3 exclusive. One of the big memes it spawned was from the very early scenes in the game, when Ethan takes his family to a mall and hisson, Jason, gets lost. During this segment you have to run through the mall yelling for him: pressing X to Jason. Ethan's recorded line of him screaming Jason kind of caught on because, well it was amusing. First there was the flash game. Now there's the song/music video:
As I said, there's no spoilers in here. This happens in the first 15 minutes of the game. Enjoy!